While it is easy to retrieve random numbers using a computer program, there are a handful of artists who use random numbers picked by hand to create unique pieces of art. One artist that I especially thought was interesting is Kenneth Martin. In this series of paintings, he has a grid of squares that are numbered. He writes down all the numbers on separate pieces of paper and picks out random numbers. Each successive pair of numbers becomes a line, creating similar but very different sets of artworks.
What I find interesting about the artist himself is that he used to paint realistic portraits and landscapes for 20 years, before turning to abstract paintings that explored spatial relationships.